The protein encoded by this gene is localized exclusively in the cell nucleus. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

54 kDa VacA-interacting protein;
54 kDa vimentin-interacting protein;
90 kDa SH3 protein interacting with Nck;
AF3p21;
dia interacting protein;
Dia-interacting protein 1;
Diaphanous protein-interacting protein;
DIP;
DIP-1;
DIP1;
NCK interacting protein with SH3 domain;
NCK-interacting protein with SH3 domain;
Nckipsd;
ORF1;
SH3 adapter protein SPIN90;
SH3 protein interacting with Nck 90 kDa;
SPIN90;
SPN90_HUMAN;
VIP54;
WASLBP;
WASP-interacting SH3-domain protein;
WISH;
wiskott- Aldrich syndrome protein-interacting protein;
Wiskott-Aldrich syndrome protein-interacting protein.

Human,Mouse,Pig,Cow,Rabbit,Sheep

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

78kD

606671

Q9NZQ3

https://www.uniprot.org/uniprotkb/Q9NZQ3

Nucleus. Colocalizes with DRF1 at membrane ruffles, and with Nck at Z-disks in mature cardiac myocytes.

Highest expression in heart, brain, skeletal muscle, kidney and liver. Lower levels in placenta, lung, small intestine and leukocytes. Weak expression in colon, thymus and spleen.

KLH conjugated synthetic peptide derived from human NCKIPSD

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.