CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. It consists of seven CEACAM (CEACAM 1, CEACAM 3-CEACAM 8) and 11 pregnancy-specific glyco-protein (PSG 1-PSG 11) members. The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/ CEACAM 5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. The function of CEACAM family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria.

Carcinoembryonic antigen; Carcinoembryonic antigen related cell adhesion molecule 5; Carcinoembryonic antigen-related cell adhesion molecule 5; CD66e; CD66e antigen; CEACAM5; CEAM5_HUMAN; DKFZp781M2392; Meconium antigen 100.

Human

IHC,IF,ICC,ELISA

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400
ELISA 1:5000-1:20000

150-200kD

1048

P06731

https://www.uniprot.org/uniprotkb/P06731

Cell membrane; Lipid-anchor, GPI-anchor

Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.

KLH conjugated synthetic peptide derived from human CEA/CD66e/CEACAM5

Mouse

Monoclonal

IgG

affinity purified by Protein A

Liquid

0.01M PBS (pH7.4) with 0.02% Proclin300.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.