The UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes are substrate-specific proteins that catalyze the transfer of GalNAc (N-acetylgalactosaminyl) to serine and threonine residues onto various proteins, thereby initiating mucin-type O-linked glycosylation in Golgi apparatus. GalNAc-TL4, also known as LGALS14 or polypeptide GalNAc transferase-like protein 4, is a 607 amino acid single-pass type II membrane protein belonging to the glycosyltransferase 2 family and GalNAc-T subfamily. Localizing to Golgi apparatus, GalNAc-TL4 utilizes manganese and calcium as cofactors and may assist with the transfer of N-acetyl-D-galactosamine to a serine or threonine residue on protein receptors. GalNAc-TL4 likely catalyzes the initial reaction in O-linked oligosaccharide biosynthesis and contains a ricin B-type lectin domain, which binds to GalNAc and contributes to glycopeptide specificity, and two conserved domains located in the glycosyltransferase region. The N-terminal domain, also known as domain A or GT1 motif, may be involved in manganese coordination and substrate binding while the C-terminal domain, also known as domain B or Gal/GalNAc-T motif, is likely involved in catalytic reaction and UDP-Gal binding. GalNAc-TL4 exists as two alternatively spliced isoforms.

GalNAc T like protein 4;
GalNAc T15; GLT18_HUMAN;
GalNAc transferase 18;
GALNT15;
GALNT18;
N acetylgalactosaminyltransferase 15 UDP N acetyl alpha D galactosamine:polypeptide;
N acetylgalactosaminyltransferase like 4;
N acetylgalactosaminyltransferase like protein 4 UDP N acetyl alpha D galactosamine:polypeptide;
Polypeptide GalNAc transferase like protein 4;
pp GaNTase like protein 4;
Protein UDP acetylgalactosaminyltransferase like protein 4;
Protein UDP acetylgalactosaminyltransferase like protein 4 UDP GalNAc:polypeptide;
Putative polypeptide N acetylgalactosaminyltransferase like protein 4;
UDP GalNAc:polypeptide N acetylgalactosaminyltransferase like protein 4.

Mouse,Human,Rat,Chicken,Dog,Cow,Horse,Rabbit,Sheep

WB

WB 1:500-2000

70kD

374378

Q6P9A2

https://www.uniprot.org/uniprotkb/Q6P9A2

Golgi Apparatus membrane; Single-pass type II membrane protein

KLH conjugated synthetic peptide derived from human GALNTL4

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.