Mael is a 434 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one HMG box DNA-binding domain. Expressed specifically in testicular tissue, Mael interacts with Ini1, mSin3B and VASA and plays an essential role in spermatogenesis, specifically by repressing and, ultimately, preventing the mobilization of transposable elements (a process that is crucial for germline integrity). Multiple isoforms of Mael exist due to alternative splicing events. The gene encoding Mael maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.

cancer/testis antigen 128;
CT128;
FLJ14904;
mael;
MAEL_HUMAN;
maelstrom homolog (Drosophila);
Maelstrom homolog;
OTTHUMP00000032344;
Protein maelstrom homolog;
RP11-102C16.1.

Human,Mouse,Rat,Dog,Pig,Cow,Horse,Sheep

IF,ICC

IF 1:50
ICC 1:100-1:400

49kD

84944

Q96JY0

https://www.uniprot.org/uniprotkb/Q96JY0

Cytoplasm. Nucleus. Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs.

Testis-specific. Expressed in various cancer cell lines, probably due to demethylation of its promoter.

KLH conjugated synthetic peptide derived from human MAEL/CT128

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.