HtrA3 is a 453 amino acid secreted protein that contains one PDZ domain, one Kazal-like domain and one IGFBP N-terminal domain. Widely expressed with particularly high expression in ovary, heart, placenta and bladder, HtrA3 functions as a probable serine protease that is thought to play an important role in placental development. HtrA3 is downregulated in ovarian tumors, suggesting an alternative role in tumor suppression. HtrA3 exists as two alternatively spliced isoforms, designated short and long. The gene encoding HtrA3 maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes.

Calpain 5;
Calpn 5;
CAPN5;
EC 3.4.21.;
High temperature requirement factor A3;
High-temperature requirement factor A3;
HtrA serine peptidase 3;
HTRA3;
HTRA3_HUMAN;
Pregnancy related serine protease;
Pregnancy-related serine protease;
Probable serine protease HTRA3;
Probable serine protease HTRA3 precursor;
PRSP;
Serine protease HTRA3;
Tasp.

Human,Mouse,Rat,Dog,Pig,Cow,Horse

WB,IHC,IF,ICC,ELISA

WB 1:500-2000
IHC 1:50-1:200
IF 1:100-1:400
ICC 1:100-1:400
ELISA 1:5000-10000

48kD

94031

P83110

https://www.uniprot.org/uniprotkb/P83110

Secreted.

Widely expressed, with highest levels in both adult and fetal heart, ovary, uterus placenta, and bladder. Isoform 1 is predominant in heart and skeletal muscle, whereas isoform 2 is predominant in placenta and kidney.

KLH conjugated synthetic peptide derived from human HTRA3/Calpain 5

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.