The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors and RNA molecules. Eukaryotic initiation factors (eIFs) are utilized in a sequence of reactions that lead to 80S ribosomal assembly and, ultimately, translation. The eukaryotic initiation factor-3 (eIF3) scaffolding structure is the largest of the eIF complexes and includes eIF3 alpha, eIF3 beta, eIF3 gamma, eIF3 delta, all of which function to control the assembly of the 40S ribosomal subunit. Association of eIF3 proteins with the 40S ribosomal subunit stabilizes eIF2-GTP-Met-tRNAiMet complex association and mRNA binding, and promotes dissociation of 80S ribosomes into 40S and 60S subunits, thereby promoting the assembly of the pre-initiation complex. Overexpression of eIF3 proteins is common in several cancers, suggesting a role for eIF3 proteins in tumorigenesis.

44kDa;
Anti EIF3S4;
eIF 3 delta;
eIF 3 RNA binding subunit;
eIF-3 RNA-binding subunit;
eIF-3-delta;
eIF3 delta;
eIF3 p42;
eIF3 p44;
eIF3g;
EIF3G_HUMAN;
EIF3S4;
EIF3S4; ;
Eukaryotic translation initiation factor 3;
Eukaryotic translation initiation factor 3 RNA binding subunit;
Eukaryotic translation initiation factor 3 RNA-binding subunit;
Eukaryotic translation initiation factor 3 subunit 4;
Eukaryotic translation initiation factor 3 subunit 4 delta 44 kD;
Eukaryotic translation initiation factor 3 subunit G;
Eukaryotic translation initiation factor 3 subunit p42;
Subunit 4 (delta 44kD);
Subunit 4 delta.

Human,Mouse,Rat,Pig,Cow,Horse

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

36kD

8666

O75821

https://www.uniprot.org/uniprotkb/O75821

Cytoplasm. Nucleus. Cytoplasm > perinuclear region. Colocalizes with AIFM1 in the nucleus and perinuclear region.

KLH conjugated synthetic peptide derived from human EIF3S4

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.