Ataxia Telangiectasia Mutated (ATM) and Rad 3-related protein (ATR) is a phosphatidylinositol kinase (PK)-related kinase which functions in response to DNA damage and repair as well as at DNA replication checkpoints during the cell cycle. ATR is a member of the DNA-PK kinases closely related to ATM and DNA-PK for which DNA stimulates the observed kinase activity. Chromosomal remodeling proteins have also been reported to associate with ATR complexes. Several known components of the NuRD complex including histone deacetylase 1 (HDAC1), HDAC2, and CHD4

ACTR; AIB1; amplified in breast cancer 1; Ataxia Telangiecasia and Rad3 Related; Ataxia telangiectasia and Rad3 related; Ataxia telangiectasia and Rad3-related protein; ATR; ATR_HUMAN; CAGH16; CBP interacting protein; CTG26; FCTCS; FRAP Related Protein 1; FRAP-related protein 1; FRP 1; FRP1; Human JTV 1; MEC1; MEC1 mitosis entry checkpoint 1 homolog; nuclear receptor coactivator 3; pCIP; protein kinase ATR; RAC3; Rad3 related protein; receptor associated coactivator 3; SCKL; SCKL1; Seckel syndrome; Serine/threonine protein kinase ATR; Serine/threonine-protein kinase ATR; steroid receptor coactivator protein 3; thyroid hormone receptor activator molecule 1; TRAM1.

Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Zebrafish,Sheep

WB

WB 1:500-2000

301kD

545

Q13535

https://www.uniprot.org/uniprotkb/Q13535

Cytoplasm. Nucleus. Note=Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus.

Ubiquitous, with highest expression in testis. Isoform 2 is found in pancreas, placenta and liver but not in heart, testis and ovary.

KLH conjugated synthetic peptide derived from human ATR

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.