Calcineurin, a major soluble calmodulin binding protein in the brain, a Ca2+/calmodulin dependent serine/threonine protein phosphatase, with a relatively narrow substrate specificity. This metalloenzyme, also known as phosphatase 2B, is a heterodimer composed of a calmodulin binding, catalytic alpha subunit 61 kDa, calcineurin A) and calcium binding beta subunit (18 kDa, calcineurin B). The Ca2+ binding subunit, calcineurin B, is immunologically conserved from yeast to mammals. The presence of 2 different calcineurin B isoforms (beta 1 and beta 2) has been reported in rat testis. The catalytic subunit of calcineurin, calcineurin A, isolated from different tissues or different organisms, exhibits some immunological heterogeneity. Further, there are at least 2 isoforms of calcineurin A in bovine brain (alpha 1 and alpha 2, 61 and 59 kDa, respectively).

Calcineurin A;
Alpha isoform formerly PPP2B;
Calcineurin A alpha;
Calcineurin A1;
CalcineurinA;
Calmodulin dependent calcineurin A subunit alpha isoform;
Calmodulin-dependent calcineurin A subunit alpha isoform;
CALN;
CALNA 1;
CALNA;
CALNA1;
CAM PRP catalytic subunit;
CAM-PRP catalytic subunit;
CCN 1;
CCN1;
CNA 1;
CNA alpha;
CNA;
CNA1;
PP2BA_HUMAN;
PPP2B;
Ppp3ca;
Protein phosphatase 2B catalytic subunit;
Protein phosphatase 3 (formerly 2B) catalytic subunit alpha isoform;
Protein phosphatase 3 catalytic subunit alpha isoform PPP3CA;
Protein phosphatase 3 catalytic subunit alpha isozyme;
Serine/threonine protein phosphatase 2B catalytic subunit alpha isoform;
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform.

Mouse,Rat,Human,Dog,Pig,Rabbit,Zebrafish

WB,IHC,IF,ICC

WB 1:500-2000
IHC 1:100-500
IF 1:100-1:400
ICC 1:100-1:400

59kD

5530

Q08209

https://www.uniprot.org/uniprotkb/Q08209

Nucleus. Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle.

Interacts with CHP1 and CHP2. Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with CRTC2, MYOZ1, MYOZ2 and MYOZ3. Interacts with DNM1L; the interaction dephosphorylates DNM1L and regulates its translocation to mitochondria. Interacts with CMYA5; this interaction represses calcineurin activity in muscle.

KLH conjugated synthetic peptide derived from human PPP3CA

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.