PC19928

货号 规格 价格(¥)
PC19928S 50ul
PC19928M 100ul

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Note:  Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.

注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。

抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。

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经典一抗-phospho-SMC3 (Ser1083) Rabbit pAb

Datasheet

Background

This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008]

Alternative Names

SMC3 (phospho S1083); p-SMC3 (phospho S1083);
CDLS2;
DKFZp686L19178;
DXhXs423e;
DXS423E;
KIAA0178;
MGC138332;
OTTHUMP00000061876;
RP6 29D12.1;
SB1.8;
Segregation of mitotic chromosomes 1;
Segregation of mitotic chromosomes like 1;
SMC 1;
SMC protein 1B;
SMC-1-beta;
SMC-1B;
SMC1;
SMC1A;
SMC1alpha;
SMC1alpha protein;
SMC1B;
SMC1B_HUMAN;
SMC1BETA;
SMC1beta protein;
SMC1L1;
SMC1L2;
SMCB;
Structural maintenance of chromosome 1 like 1 protein;
Structural maintenance of chromosome 1 like 2 protein;
Structural maintenance of chromosomes 1A;
Structural maintenance of chromosomes 1B;
Structural maintenance of chromosomes protein 1B.

Reactivity

Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep

Application

WB

Recommended Dilution

WB 1:500-2000

Application Image

Mol Weight

141kD

Gene ID

9126

UniProt

Q9UQE7

Uniprot link

Subcellular location

Nucleus. Chromosome. Chromosome > centromere. Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation.

Specificity

Immunogen

KLH conjugated synthesised phosphopeptide derived from human SMC3 around the phosphorylation site of Ser1083

Source

Rabbit

Clonality

Polyclonal

Isotype

IgG

Purification

affinity purified by Protein A

Formulation

Liquid

Buffer

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Concentrate

Storage Condition

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

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邮箱:market@ab-mart.com

应聘职位:hr@ab-mart.com

订购专线:4006-123-828

销售电话:13916964679(微信同号)

技术支持:15618194176(微信同号)

华南经销商负责(广东,广西,福建,海南):
程经理:手机18616261485(微信同号)
华北经销商负责(北京,天津,河北):
徐经理:手机15618191473(微信同号)
南方经销商负责:

陆经理:手机13122837132(微信同号)
北方及西南经销商负责:

张经理:手机13122150513(微信同号)

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