PC1468

货号 规格 价格(¥)
PC1468S 50ul
PC1468M 100ul

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Note:  Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.

注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。

抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。

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   植物BPP法变性蛋白提取

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经典一抗-MDR1/P Glycoprotein Rabbit pAb

Datasheet

Background

P Glycoprotein, the product of the MDR1 gene, is expressed in distinct non-malignant cells, typically cells with secretory and excretory functions. It is assumed to function as an ATP-dependent drug efflux pump with broad substrate specificity. The highest expression of P Glycoprotein has been observed in kidney (proximal tubules), liver (bile canaliculi), adrenal gland and intestine, suggesting that the primary role of P Glycoprotein is in the normal secretion of physiological metabolites and ingested chemicals into bile, urine and the lumen of the intestinal tract. Elevated levels of P Glycoprotein have also been reported in multidrug-resistant cell lines and in colon, endometrial, ovarian, and breast tumors, as well as in sarcomas and leukemias / lymphomas.

Alternative Names

ABC20;
ABCB1;
ATP binding cassette, sub family B (MDR/TAP), member 1;
ATP-binding cassette sub-family B member 1;
CD243;
CLCS;
Colchicin sensitivity;
Doxorubicin resistance;
GP170;
MDR1;
MDR1_HUMAN;
Multidrug resistance 1;
Multidrug resistance protein 1;
P glycoprotein 1;
P gp;
P-glycoprotein 1;
PGY1.

Reactivity

Human,Mouse,Rat

Application

WB,IF,ICC,FC

Recommended Dilution

WB 1:500-2000
IF 1:100-1:400
ICC 1:100-1:400
FC 1:100

Application Image

Mol Weight

141kD

Gene ID

5243

UniProt

P08183

Uniprot link

Subcellular location

Cell membrane; Multi-pass membrane protein.

Specificity

Expressed in liver, kidney, small intestine and brain.

Immunogen

KLH conjugated synthetic peptide derived from human MDR1

Source

Rabbit

Clonality

Polyclonal

Isotype

IgG

Purification

affinity purified by Protein A

Formulation

Liquid

Buffer

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Concentrate

Storage Condition

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

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      微信客服

邮箱:market@ab-mart.com

应聘职位:hr@ab-mart.com

订购专线:4006-123-828

销售电话:13916964679(微信同号)

技术支持:15618194176(微信同号)

华南经销商负责(广东,广西,福建,海南):
程经理:手机18616261485(微信同号)
华北经销商负责(北京,天津,河北):
徐经理:手机15618191473(微信同号)
南方经销商负责:

陆经理:手机13122837132(微信同号)
北方及西南经销商负责:

张经理:手机13122150513(微信同号)

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