EME2 forms a heterodimer with MUS81 (MIM 606591) that functions as an XPF (MIM 278760)-type flap/fork endonuclease in DNA repair (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008]
Eme2 is a 379 amino acids nuclear protein. As a member of the Eme2/Mms4 family, Eme2 associates with MUS81 to constitute a DNA structure-specific endonuclease. The MUS81-Eme2 complex cleaves branched DNA structures, especially those arising during stalled DNA replication such as replication forks and 3' DNA flaps. Expressed as two alternatively spliced isoforms, Eme2 is encoded by a gene located on human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. Defects in the gene encoding WDR59 may be associated with the rare disorder Rubinstein-Taybi syndrome or Crohn's disease, which is a gastrointestinal inflammatory condition.

EME1, S. pombe, homolog of, 2;
Eme2;
EME2_HUMAN;
essential meiotic endonuclease 1 homolog 2;
essential meiotic endonuclease 1, S.pombe, homolog of, 2;
essential meiotic structure-specific endonuclease subunit 2;
gs125;
homolog of yeast EME1 endonuclease 2;
Probable crossover junction endonuclease EME2;
SLX2 structure-specific endonuclease subunit homolog B;
SLX2B.

Human,Mouse,Rat,Pig,Cow

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

41kD

197342

A4GXA9

https://www.uniprot.org/uniprotkb/A4GXA9

Nucleus.

KLH conjugated synthetic peptide derived from human EME2

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.