The connexin family of proteins form hexameric complexes called “connexons” that facilitate movement of low molecular weight proteins between cells via gap junctions (1). Connexin proteins share a common topology of 4 transmembrane alpha-helical domains, two extracellular loops, a cytoplasmic loop, and cytoplasmic N- and C-termini (2). Many of the key functional differences arise from specific amino-acid substitutions in the most highly conserved domains, the transmembrane and extracellular regions (2). Each of the approximately 20 connexin isoforms produces channels with distinct permeabilities and electrical and chemical sensitivities; therefore, one connexin usually cannot fully substitute for another (2). Consequently, a wide variety of malignant phenotypes associate with decreased connexin expression and gap junction communication, dependent on the particular connexin that is effected (3, 2). For instance, deletion of the gene encoding connexin 50, normally expressed in the lens, produces cataracts, though not as severe as with deletion of connexin 46 (4).

CAE; CAE1; cataract, zonular pulverulent 1 (FY-linked); Connexin 50; Connexin50; Connexin-50; Cx50; CXA8_HUMAN; Gap junction alpha 8 protein; Gap junction alpha-8 protein; Gap junction membrane channel protein alpha 8 (connexin 50); gap junction protein, alpha 8, 50kD; Gja8; Lens fiber protein MP70.

Mouse,Human,Rat,Chicken,Dog,Cow,Rabbit,Sheep

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

48kD

2703

P48165

https://www.uniprot.org/uniprotkb/P48165

Cell membrane. Cell junction; gap junction.

Eye lens.

KLH conjugated synthetic peptide derived from human GJA8/Connexin 50

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.