PC1005

货号 规格 价格(¥)
PC1005S 50ul
PC1005M 100ul

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Note:  Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.

注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。

抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。

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   蛋白质免疫共沉淀

   蛋白质印迹

   免疫荧光

   免疫组化

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   植物BPP法变性蛋白提取

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经典一抗-Cytokeratin 2 Rabbit pAb

Datasheet

Background

Keratins are a group of water-insoluble proteins that form monofilaments, a class of intermediate filament. These filaments form part of the cytoskeletal complex in epidermis and in most other epithelial tissues. Nineteen human epithelial keratins are resolved with two-dimensional gels electrophoresis (1). These can be divided into acid (pI 6.0) subfamilies. The acidic keratins have molecular weights of 56.5, 55, 51, 50, 50’, 48, 46, 45 and 40 kD. The basic keratins have molecular weights of 65-67, 64, 59, 58, 56 and 52kD. Members of the acidic and basic subfamilies are found together in pairs. The composition of keratin pairs varies with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state (2-4). The 56.5/65-67kD pair is present in keratinized (differentiated) epidermis. The 55/64kD pair is characteristic of normal (corneal-type) epithelial differentiation (1,2). The 51/59kD pair is characteristic of the stratified squamous epithelial of internal organism such as esophagus and tongue (1,3). The 51/58kD pair is a keratinocyte marker; this pair is present in almost all stratified epithelia irrespective of the state of cellular stratification (1,2). The 48/56kD pair is characteristic of hyperproliferative (de-differentiated) keratinocytes (1,5). The 45/52kD pair and to a lesser extent, the 46/54kD pair are characteristic of simple epithelia (1). The 40kD keratin is present in most epithelia except adult epidermis (1).

Alternative Names

CK2; Cytokeratin 2; KRT2B; keratin 76; CK 2P; CK2P; Cytokeratin 2P; Cytokeratin2; Cytokeratin2P; HUMCYT 2A; HUMCYT2A; K2P; Keratin 2p; Keratin 76; Keratin type II cytoskeletal 2 ora; Keratin2p; Keratin76; KRT 2B;KRT 2P; KRT 76; KRT2B; KRT2P; KRT76; K22O_HUMAN.

Reactivity

Rat,Human,Mouse

Application

IHC,IF,ICC

Recommended Dilution

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

Application Image

Mol Weight

66kD

Gene ID

51350

UniProt

P35908

Uniprot link

Subcellular location

Specificity

Immunogen

KLH conjugated synthetic peptide derived from human CK2

Source

Rabbit

Clonality

Polyclonal

Isotype

IgG

Purification

affinity purified by Protein A

Formulation

Liquid

Buffer

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Concentrate

Storage Condition

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

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邮箱:market@ab-mart.com

应聘职位:hr@ab-mart.com

订购专线:4006-123-828

销售电话:13916964679(微信同号)

技术支持:15618194176(微信同号)

华南经销商负责(广东,广西,福建,海南):
程经理:手机18616261485(微信同号)
华北经销商负责(北京,天津,河北):
徐经理:手机15618191473(微信同号)
南方经销商负责:

陆经理:手机13122837132(微信同号)
北方及西南经销商负责:

张经理:手机13122150513(微信同号)

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