Neurexins comprise a family of neuronal cell surface proteins, which include neurexin I (NRXN1), neurexin II (NRXN2), neurexin III (NRXN3) and CASPR (neurexin IV). Neurexins I-III are expressed as and ∫ isoforms. The isoforms are made of three cassettes, which contain two LNS (laminin A, neurexins, sex hormone-binding)-domains separated by EGF domains, followed by a transmembrane region and a 55 amino acid cytoplasmic C-terminal. The isoforms bind to neurexophilins at the second LNS site, and to the excitatory neurotoxin -latrotoxin. The ∫ isoforms have only one LNS-domain, bind to neuroligins and play a role in the formation and remodeling of synapses. CASPR (for contactin-associated protein 1, also designated paranodin in mouse), contains an extracellular domain similar to the other three neurexins, and binds to the surface glycoprotein contactin. CASPR and the closely related CASPR2, a mammalian homolog of Drosophila neurexin IV (Nrx-IV), demarcate distinct subdomains in myelinated axons. Specifically, CASPR exists at the paranodal junctions, while CASPR2 co-localizes with Shaker-like K+ channels in the juxtaparanodal region. CASPR may play a role in the communication of glial cells and neurons during development.

Neurexin4; caspr 1; Caspr; Caspr1; Cntnap 1; Cntnap1; CNTP 1; CNTP1; CNTP1_HUMAN; Contactin associated protein 1; Contactin-associated protein 1; MHDNIV; NCP 1; NCP1; Neurexin 4; Neurexin IV; Neurexin-4; Nrxn 4; Nrxn4; p190; Paranodin.

Human,Mouse,Rat,Dog,Pig,Cow,Horse

IF,ICC,FC

IF 1:100-500
ICC 1:100-1:400
FC 3ug/Test

154kD

8506

P78357

https://www.uniprot.org/uniprotkb/P78357

Membrane.

Predominantly expressed in brain. Weak expression detected in ovary, pancreas, colon, lung, heart, intestine and testis.

KLH conjugated synthetic peptide derived from human CASPR/Neurexin4

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.