Genes encoding LIM domain-binding factors were initially isolated in a screen for proteins that physically interact with the LIM domains of nuclear proteins (summarized by Semina et al., 1998 [PubMed 9799849]). These proteins, such as the one encoded by the LDB2 gene, are capable of binding to a variety of transcription factors and are likely to function at enhancers to bring together diverse transcription factors and form higher order activation complexes or to block formation of such complexes (Jurata and Gill, 1997 [PubMed 9315627]). The family of genes encoding LIM domain-binding factors includes 2 members isolated from the mouse, Clim1 (Bach et al., 1997 [PubMed 9192866]) and Clim2/Lbd1/Nli (Agulnick et al., 1996 [PubMed 8918878]; Jurata et al., 1996 [PubMed 8876198]; Bach et al., 1997 [PubMed 9192866]) and their homologs cloned from the frog, chicken, and fly. The fact that LIM domain-binding factors are likely to be involved in the coordination of the transcriptional activity of many diverse factors might implicate them in human phenotypes characterized by multiple affected sites.[supplied by OMIM, Jul 2010]

Carboxyl terminal LIM domain binding protein 1;
Carboxyl terminal LIM domain protein 1;
Carboxyl-terminal LIM domain-binding protein 1;
CLIM 1;
CLIM-1;
CLIM1;
LDB 1;
LDB 2;
LDB-2;
LDB1;
LDB2;
LDB2_HUMAN;
LIM binding domain 2;
LIM domain binding 2;
LIM domain binding factor 2;
LIM domain binding factor CLIM 1;
LIM domain binding factor CLIM1;
LIM domain binding protein 2;
LIM domain-binding factor CLIM1;
LIM domain-binding protein 2;
OTTHUMP00000158632;
OTTHUMP00000217823;
OTTHUMP00000217824;
OTTHUMP00000217825;
OTTHUMP00000217827.

Human,Mouse,Rat,Dog,Cow,Horse,Rabbit,Cat

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

43kD

9079

O43679

https://www.uniprot.org/uniprotkb/O43679

Nucleus.

KLH conjugated synthetic peptide derived from human LDB2

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.