This gene encodes a protein that has both DNA-dependent ATPase and DNA helicase activities and belongs to the ATPases associated with diverse cellular activities (AAA+) protein family. The encoded protein associates with several multisubunit transcriptional complexes and with protein complexes involved in both ATP-dependent remodeling and histone modification. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

49 kDa TATA box binding protein interacting protein;
49 kDa TATA box-binding protein-interacting protein;
49 kDa TBP interacting protein;
49 kDa TBP-interacting protein;
54 kDa erythrocyte cytosolic protein;
ECP-54;
ECP54;
ERYTHROCYTE CYTOSOLIC PROTEIN, 54-KD;
INO80 complex subunit H;
NMP 238;
Nuclear matrix protein 238;
Pontin 52;
PONTIN;
RuvB like 1;
RuvB-like 1;
RUVB1_HUMAN;
RVB1;
TAP54 alpha;
TAP54-alpha;
TIP49;
TIP49A;
TIP60 associated protein 54 alpha;
TIP60-associated protein 54-alpha.

Mouse,Human,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Zebrafish,Sheep

WB,IHC,IF,ICC

WB 1:500-2000
IHC 1:100-500
IF 1:100-1:400
ICC 1:100-1:400

50kD

8607

Q9Y265

https://www.uniprot.org/uniprotkb/Q9Y265

Nucleus matrix. Nucleus > nucleoplasm. Cytoplasm. Membrane. Cytoplasm > cytoskeleton > centrosome. Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol, although it is also present in the cytoplasm and associated with the cell membranes. In prophase and prometaphase it is located at the centrosome and the branching microtubule spindles. After mitotic nuclear membrane disintigration it accumulates at the centrosome and sites of tubulin polymerization. As cells pass through metaphase and into telophase it is located close to the centrosome at the early phase of tubulin polymerization. In anaphase it accumulates at the zone of tubule interdigitation. In telophase it is found at polar tubule overlap, and it reappears at the site of chromosomal decondensation in the daughter cells.

Ubiquitously expressed with high expression in heart, skeletal muscle and testis.

KLH conjugated synthetic peptide derived from human RUVBL1

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.