This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I. [provided by RefSeq, Jul 2008]

1alpha(OH)ase;
25-hydroxyvitamin D(3) 1-alpha-hydroxylase;
25-hydroxyvitamin D-1 alpha hydroxylase;
25-OHD-1 alpha-hydroxylase;
Calcidiol 1-monooxygenase;
CP27B_HUMAN;
CP2B;
CYP1;
CYP1ALPHA;
CYP27B;
Cytochrome p450 27B1;
Cytochrome p450 27B13;
Cytochrome P450 family 27 subfamily B polypeptide 1;
Cytochrome P450 subfamily XXVIIB (25-hydroxyvitamin D-1-alpha-hydroxylase) polypeptide 1;
Cytochrome P450 subfamily XXVIIB polypeptide 1;
Cytochrome P450C1 alpha;
Cytochrome P450VD1-alpha;
mitochondrial;
P450C1 alpha;
P450c1;
P450C1-alpha;
P450VD1-alpha;
PDDR;
VD3 1A hydroxylase;
VDD1;
VDDR;
VDDR I;
VDDRI;
VDR.

Mouse,Human,Rat,Dog,Pig,Cow,Horse,Sheep

WB

WB 1:500-2000

57kD

1594

O15528

https://www.uniprot.org/uniprotkb/O15528

Mitochondrion membrane.

Kidney.

KLH conjugated synthetic peptide derived from human CYP27B1

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.