Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the being a source of oxidative stress. Required for the folding of cell, thereby being a source of oxidative stress.

Endoplasmic oxidoreductin-1-like protein B;
ERO1-L-beta; ERO1B_HUMAN;
ERO1-like protein beta;
Oxidoreductin-1-L-beta.

Mouse,Human,Rat,Rabbit,GuineaPig

WB

WB 1:500-2000

50kD

56605

Q86YB8

https://www.uniprot.org/uniprotkb/Q86YB8

Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Note: The association with ERP44 may be essential for its retention in the endoplasmic reticulum.

Highly expressed in the digestive tract, including the duodenum and lower digestive tract. In the stomach, highly expressed in enzyme-producing chief cells (at protein level). In the pancreas, expressed in islets of Langerhans and, at lower levels, in enzyme-secreting cells (at protein level). Detected at low level in many other tissues.

KLH conjugated synthetic peptide derived from human ERO1LB

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.