OTUD7B (OTU domain-containing protein 7B), also known as ZA20D1 or Cezanne, is an 843 amino acid protein that localizes to both the nucleus and the cytoplasm. Expressed in a variety of tissues, including liver, kidney, heart and immature B-cells, OTUD7B functions to hydrolyze branched and linear forms of polyubiquitin, specifically deubiquinating Lys-48- and Lys-63-linked polyubiquitin chains. Via its ability to deubiquinate target proteins, OTUD7B regulates the inflammatory response within the cell and may play a role in cell survival. More specifically, OTUD7B forms a negative feedback loop in pro-inflammatory signaling, thereby suppressing NFⅹB activity and helping to resolve inflammatory responses. OTUD7B contains one C-terminal A20-type zinc finger, one OTU domain and one N-terminal TRAF-binding domain through which it conveys its deubiquitinating activity.

Cellular zinc finger anti NF kappa B protein;
Cellular zinc finger anti-NF-kappa-B protein;
CEZANNE;
HGNC:16683;
OTU domain containing protein 7B;
OTU domain containing protein 7B;
OTU domain-containing protein 7B;
OTU7B_HUMAN;
OTUD7B;
ZA20D1;
Zinc finger A20 domain containing protein 1;
Zinc finger A20 domain-containing protein 1;
Zinc finger protein Cezanne.

Rat,Human,Mouse,Cow,Horse,Sheep

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

92kD

56957

Q5XG92

https://www.uniprot.org/uniprotkb/Q5XG92

Cytoplasm. Nucleus.

Widely expressed. Abundant in kidney, heart and fetal liver. Expressed differentially among B-cells at distinct developmental stages. Higher expression seen in primary immature B-cells as compared to the mature cells.

KLH conjugated synthetic peptide derived from human Cezanne

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.