Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]

h-VPS45;
H1;
H1VPS45;
HGNC:14579;
hlVps45;
Leucocyte vacuolar protein sorting 45;
OTTHUMP00000014482;
Vacuolar protein sorting 45 homolog (S. cerevisiae);
Vacuolar protein sorting 45A (yeast homolog);
Vacuolar protein sorting 45A;
Vacuolar protein sorting 45B (yeast);
Vacuolar protein sorting-associated protein 45;
VPS45;
VPS45_HUMAN;
VPS45A;
VPS45B;
VPS54A;
VSP45;
VSP45A.

Mouse,Human,Rat,Dog,Pig,Cow,Horse,Sheep

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

65kD

11311

Q9NRW7

https://www.uniprot.org/uniprotkb/Q9NRW7

Golgi apparatus membrane. Endosome membrane. Associated with Golgi/endosomal vesicles and the trans-Golgi network.

Ubiquitous. Expression was highest in testis, heart and brain, intermediate in kidney, spleen, prostate, ovary, small intestine and thymus and low in lung, skeletal muscle, placenta, colon, pancreas, peripheral blood leukocytes and liver.

KLH conjugated synthetic peptide derived from human VPS45A

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.