The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic Alpha/Beta horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. LRRTM1 (leucine rich repeat transmembrane neuronal 1) is a 522 amino acid single-pass type I membrane protein that localizes to the endoplasmic reticulum and contains ten LRR repeats. Expressed predominately in forebrain tissue, LRRTM1 is thought to be involved in the development of forebrain structures, specifically by influencing axon trafficking, as well as neuronal differentiation and connectivity. Human LRRTM1 shares 96% amino acid identity with its mouse counterpart, suggesting a conserved role between species. Defects in the gene encoding LRRTM1 may be associated with the pathogenesis of several common neurodevelopmental disorders.

Leucine rich repeat transmembrane neuronal 1; Leucine rich repeat transmembrane neuronal 1 protein; Leucine-rich repeat transmembrane neuronal protein 1; LRRT1_HUMAN; LRRTM1; Lrrtm1 leucine rich repeat transmembrane neuronal 1; OTTHUMP00000194829; 4632401D06Rik; AW125451; FLJ32082.

Human,Mouse,Rat,Chicken,Dog,Pig,Cow

WB

WB 1:500-2000

55kD

347730

Q86UE6

https://www.uniprot.org/uniprotkb/Q86UE6

Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein (By similarity).

Predominantly expression in forebrain regions including thalamus and cerebral cortex.

KLH conjugated synthetic peptide derived from human LRRTM1

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.