The exosome is a multisubunit complex composed of several highly conserved subunits, some of which are 3’ to 5’ exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich (ARE) elements in their untranslated 3’ region. EXOSC5 (Exosome component 5), also known as Exosome complex exonuclease RRP46 and CML28 (Chronic myelogenous leukemia tumor antigen 28), is one of at least eleven components of the exosome complex and is required for processing of 7S pre-RNA to mature 5.8S rRNA. Located in the nucleus, EXOSC5 interacts with both EXOSC1 and EXOSC7. EXOSC5 is exclusively expressed in normal testis, though is found to be highly expressed in many hematopoietic and epithelial tumor cell lines, suggesting that it may be an appropriate target for antigen-specific immunotherapy.

Chronic myelogenous leukemia tumor antigen 28;
CML28;
EXOS5_HUMAN;
EXOSC 5;
Exosc5;
Exosome complex component rrp46;
exosome complex exonuclease RRP46;
Exosome component 5;
exosome component Rrp46;
hRrp46p;
p12B;
Ribosomal RNA processing protein 46;
Ribosomal RNA processing protein 46, S. cerevisiae, homolog of;
Ribosomal RNA-processing protein 46;
RRP41B;
RRP46;
Rrp46p.

Mouse,Human,Rat,Dog,Pig,Cow,Horse,Sheep

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

25kD

56915

Q9NQT4

https://www.uniprot.org/uniprotkb/Q9NQT4

Nucleus; nucleolus. Cytoplasm. Nucleus.

Highly expressed in a variety of hematopoietic and epithelial tumor cell lines, but not in normal hematopoietic tissues or other normal tissue, with the exception of testis.

KLH conjugated synthetic peptide derived from human EXOSC5

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.