The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic /∫ horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. The primary function of these motifs is to provide a versatile structural framework to mediate the formation of protein-protein interactions. LRRs are present in a variety of proteins with diverse structure and function, including innate immunity and nervous system development. Several human diseases are associated with mutations in genes encoding LRR-containing proteins. The leucine-rich repeat-containing protein 21 (LRRC21), also designated leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1 (LRIT1) or PAL, is a 623 amino acid protein that contains 6 LRR repeats. LRRC21 is expressed in retina and may play a role in phototransduction.

DKFZP434K091;
Fibronectin type III, immunoglobulin and leucine rich repeat domains 9;
FIGLER9;
immunoglobulin-like domain and transmembrane domain-containing protein 1;
Leucine-rich repeat;
Leucine-rich repeat, immunoglobulin-like and transmembrane domains 1;
Leucine-rich repeat-containing protein 21;
Lrit1;
LRIT1_HUMAN;
LRRC21;
PAL;
Photoreceptor-associated LRR superfamily protein;
Retina-specific protein PAL.

Mouse,Human,Rat,Cow,Horse

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

66kD

26103

Q9P2V4

https://www.uniprot.org/uniprotkb/Q9P2V4

Endoplasmic reticulum membrane.

KLH conjugated synthetic peptide derived from human LRIT1

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.