Spectrin, an Actin binding protein that is a major component of the cytoskeletal superstructure of the erythrocyte plasma membrane, is essential in determining the properties of the membrane including its shape and deformability. Spectrins function as membrane organizers and stabilizers, composed of nonhomologous å and ∫ chains, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Spectrin ∫ V is a non-erythrocytic member of the ∫-spectrin family. It is expressed in brain and pancreatic islets and localizes to the cytoplasm of the cytoskeleton and cell cortex. Spectrin ∫ V is a 2,564 amino acid protein with four isoforms due to alternative splicing events.

1110067P07Rik;
BA48B24;
BA48B24.1;
BM 016;
FLJ31290;
KIAA1844;
MGC10753;
OTTHUMP00000019380;
OTTHUMP00000019382;
PRO1741;
wac;
WAC_HUMAN;
WW domain containing adapter protein with coiled coil;
WW domain containing adaptor with coiled coil;
WW domain-containing adapter protein with coiled-coil;
Wwp4.

Mouse,Human,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep

WB

WB 1:500-2000

71kD

51322

Q9NRC6

https://www.uniprot.org/uniprotkb/Q9NRC6

Cytoplasm > cytoskeleton. Detected prominently in the outer segments of photoreceptor rods and cones and in the basolateral membrane and cytosol of gastric epithelial cells.

Expressed at very low levels in many tissues, with strongest expression in cerebellum, spinal cord, stomach, pituitary gland, liver, pancreas, salivary gland, kidney, bladder, and heart.

KLH conjugated synthetic peptide derived from human WAC

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.