This gene encodes an unconventional myosin. This protein differs from other myosins in that it has a long N-terminal extension preceding the conserved motor domain. Studies in mice suggest that this protein is necessary for actin organization in the hair cells of the cochlea. Mutations in this gene have been associated with profound, congenital, neurosensory, nonsyndromal deafness. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Read-through transcripts containing an upstream gene and this gene have been identified, but they are not thought to encode a fusion protein. Several alternatively spliced transcript variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]

DFNB3;
MYO15;
MYO15_HUMAN;
MYO15A;
Myosin XV;
Myosin XVA;
Unconventional myosin 15;
Unconventional myosin XV;
Unconventional myosin-15;
Unconventional myosin-XV.

Rat,Human,Mouse,Dog,Cow,Horse,Rabbit,Sheep

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

395kD

51168

Q9UKN7

https://www.uniprot.org/uniprotkb/Q9UKN7

Cell projection > stereocilium. Cytoplasm > cytoskeleton. Localizes to stereocilium tips in cochlear and vestibular hair cells.

Highly expressed in pituitary. Also expressed at lower levels in adult brain, kidney, liver, lung, pancreas, placenta and skeletal muscle. Not expressed in brain. In the pituitary, highly expressed in anterior gland cells.

KLH conjugated synthetic peptide derived from human MYO15A

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.