The kinesins constitute a large family of microtubule-dependent motor proteins, which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport and membrane trafficking events including endocytosis and transcytosis. KIF1C is a member of the KIF1/Unc104 family of kinesin-like proteins, which are involved in the transport of mitochondria or synaptic vesicles in axons. The human KIF1A gene encodes a neuron-specific motor protein that delivers synaptic vesicle precursors to nerve terminals. KIF1A is a monomeric, globular molecule and has rapid anterograde motor activity (1.2 microns/s). KIF1A-mediated axonal transport plays a critical role in viability, maintenance and function of neurons, particularly mature neurons. KIF1A is associated with organelles that contain synaptic vesicle proteins such as synaptotagmin, synaptophysin and Rab 3A.

ATSV; Axonal transporter of synaptic vesicles; C2orf20; hUnc 104; hUnc-104;
hunc104; Kif1a; KIF1A related protein; KIF1A_HUMAN; kinesin like protein; kinesin like protein KIF1A; Kinesin-like protein KIF1A; Microtubule based motor; Microtubule based motor KIF1A; Microtubule-based motor KIF1A;
Unc 104 and KIF1A related protein; Unc 104; Unc-104- and KIF1A-related protein.

Mouse,Human,Rat,Chicken,Dog,Pig,Cow,Sheep

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

191kD

547

Q12756

https://www.uniprot.org/uniprotkb/Q12756

Cytoplasm, cytoskeleton. Note=Expressed in distal regions of neurites.

Expressed in neurons.

KLH conjugated synthetic peptide derived from human KIF1A

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.