Dermokine, also known as DMKN, ZD52F10 or UNQ729, is a 476 amino acid secreted protein that belongs to the dermokine family and exists as 15 alternatively spliced isoforms, the most notable of which are designated and ∫. Existing as a homooligomer that can either homodimerize or homotrimerize, Dermokine is expressed in the epidermis, as well as in the epithelia of the lung and small intestine where it is thought to function as a regulator of keratinocyte differentiation, possibly playing a role in inflammatory responses. The gene encoding Dermokine maps to human chromosome 19, which consists of over 63 million bases, houses approximately 1,400 genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin (Ig) superfamily members, including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family and Fc receptors (FcRs).

Dermokineβ; Dermokine-β; DMKN;Dermokine beta; Dermokine delta 1; Dermokine delta 5a; Dermokine delta 5b; Dermokine gamma 1; Dermokine gamma 2; UNQ729; ZD52F10 protein; Epidermis-specific secreted protein SK30/SK89; DMKN_HUMAN.

Rat,Human

IHC,IF,ICC

IHC 1:100-500
IF 1:50-200
ICC 1:100-1:400

45kD

93099

Q6E0U4

https://www.uniprot.org/uniprotkb/Q6E0U4

Secreted.

Expressed in epidermis; in the spinous and granular layers and in placenta. Also found in the epithelia of the small intestine, macrophages of the lung and endothelial cells of the lung. Isoform 15 is expressed in epidermis and placenta. Isoform 1 is expressed in epidermis.

KLH conjugated synthetic peptide derived from human Dermokine beta

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.