SARM, also known as SAMD2, SARM1 or KIAA0524, is a 724 amino acid protein that localizes to the cytoplasm and contains one TIR domain and two sterile alpha motif (SAM) domains. Expressed predominately in liver and kidney and present at lower levels in placenta, SARM interacts with TICAM-1 and, via this interaction, blocks the transcriptional activation activity of TICAM-1 and functions as a negative regulator of Toll-like receptor signaling. Additionally, SARM is thought to be involved in innate immune responses and may also play a role in the negative regulation of NFⅹB activation. SARM exists as two alternatively spliced isoforms that are encoded by a gene which maps to human chromosome 17.

FLJ36296;
KIAA0524;
MyD88-5;
SAM and ARM-containing protein;
SAM domain-containing protein 2;
SAMD2;
SARM 1;
SARM1;
SARM1_HUMAN;
Sterile alpha and Armadillo repeat protein;
sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila;
sterile alpha and HEAT/Armadillo motifs-containing protein;
sterile alpha and TIR motif containing 1;
Sterile alpha and TIR motif-containing protein 1;
Sterile alpha and TIR motifs-containing protein 1;
Sterile alpha motif domain-containing protein 2;
Tir-1 homolog.

Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit

IHC,IF,ICC

IHC 1:100-500
IF 1:50-200
ICC 1:100-1:400

80kD

23098

Q6SZW1

https://www.uniprot.org/uniprotkb/Q6SZW1

Cytoplasm.

Predominantly expressed in kidney and liver. Expressed at lower level in placenta.

KLH conjugated synthetic peptide derived from human SARM1

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.