This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2011]

Activator of G protein signaling 1;
Activator of G protein signaling;
Activator of G-protein signaling 1;
AGS 1;
AGS1;
Dexamethasone induced ras related protein 1;
Dexamethasone-induced ras protein 1;
Dexamethasone-induced Ras-related protein 1;
Dexras 1;
MGC:26290;
RAS dexamethasone induced 1;
Ras protein, Dexamethasone-induced, 1;
Ras related protein;
RASD 1;
Rasd1;
RASD1_HUMAN.

Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep

WB,IHC,IF,ICC

WB 1:500-2000
IHC 1:100-500
IF 1:100-1:400
ICC 1:100-1:400

31kD

51655

Q9Y272

https://www.uniprot.org/uniprotkb/Q9Y272

Cell membrane. Cytoplasm > perinuclear region. Nucleus.

Expressed in a variety of tissues including heart, cardiovascular tissues, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, gastrointestinal and reproductive tissues.

KLH conjugated synthetic peptide derived from human Dexras1

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.