Summary: This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L2, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L2, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L2 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Several alternatively spliced variants of this gene have been reported. [provided by RefSeq, Jul 2008].

Galactosyltransferase associated protein kinase p58/GTA; CD11B_HUMAN; CDK11B; CDC2L1; PITSLREA; PK58; CDK11-p110; CDK11-p46; CDK11-p58; CDK11; CDK11 p110; CDK11 p46; CDK11 p58; CLK-1; p58; p58CDC2L1; p58CLK-1; p58 CLK-1; PK58; Cyclin-dependent kinase 11B; Cell division cycle 2-like protein kinase 1; Cell division protein kinase 11B; Galactosyltransferase-associated protein kinase p58/GTA; PITSLRE serine/threonine-protein kinase CDC2L1.

Human,Mouse,Rat,Dog,Pig,Cow,Rabbit,Sheep

IF,ICC

IF 1:50
ICC 1:100-1:400

93kD

984

P21127

https://www.uniprot.org/uniprotkb/P21127

Cytoplasm. Nucleus.

Expressed ubiquitously. Some evidence of isoform-specific tissue distribution.

KLH conjugated synthetic peptide derived from human CDK11

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.