PC4736

货号 规格 价格(¥)
PC4736S 50ul
PC4736M 100ul

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Note:  Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.

注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。

抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。

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经典一抗-CD168 Rabbit pAb

Datasheet

Background

The CD168 antigen is a non-integral cell surface hyaluronan receptor and intracellular protein. When hyaluronan binds to CD168, the phosphorylation of a number of proteins, including the focal adhesion kinase occurs. CD168 activation regulates various cellular processes including cell migration, proliferation, signaling, regulation of gene expression, cell differentiation, morphogenesis, and metastasis via both extracellular and intracellular pathways. CD168 is involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. CD168 is also a subunit of the HARC complex. CD168 knockdown in human embryonic stem cells results in downregulation of several pluripotency markers, induction of early extraembryonic lineages, loss of cell viability, and changes in cell cycle.

Alternative Names

CD168 antigen; HMMR; HMMR_HUMAN; Hyaluronan mediated motility receptor; Hyaluronan-mediated motility receptor (RHAMM); IHABP; Intracellular hyaluronic acid-binding protein; Intracellular hyaluronic acid-binding protein; MGC119494; MGC119495; Receptor for hyaluronan-mediated motility; RHAMM; Hyaluronan mediated motility receptor.

Reactivity

Human,Mouse,Rat,Cow,Horse

Application

WB,IHC,IF,ICC,FC

Recommended Dilution

WB 1:500-2000
IHC 1:100-500
IF 1:100-1:400
ICC 1:100-1:400
FC 1:100

Application Image

Mol Weight

84kD

Gene ID

3161

UniProt

O75330

Uniprot link

Subcellular location

Cell surface. Cytoplasm.

Specificity

Expressed in breast cancer cell lines and in normal breast tissue.

Immunogen

KLH conjugated synthetic peptide derived from human CD168/RHAMM

Source

Rabbit

Clonality

Polyclonal

Isotype

IgG

Purification

affinity purified by Protein A

Formulation

Liquid

Buffer

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Concentrate

Storage Condition

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

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北方及西南经销商负责:

张经理:手机13122150513(微信同号)

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      微信客服

邮箱:market@ab-mart.com

应聘职位:hr@ab-mart.com

订购专线:4006-123-828

销售电话:13916964679(微信同号)

技术支持:15618194176(微信同号)

华南经销商负责(广东,广西,福建,海南):
程经理:手机18616261485(微信同号)
华北经销商负责(北京,天津,河北):
徐经理:手机15618191473(微信同号)
南方经销商负责:

陆经理:手机13122837132(微信同号)
北方及西南经销商负责:

张经理:手机13122150513(微信同号)

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      微信客服

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