This gene encodes a member of the pterin-4-alpha-carbinolamine dehydratase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein functions as both a dehydratase involved in tetrahydrobiopterin biosynthesis, and as a cofactor for HNF1A-dependent transcription. A deficiency of this enzyme leads to hyperphenylalaninemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

4 alpha hydroxy tetrahydropterin dehydratase;
4-alpha-hydroxy-tetrahydropterin dehydratase;
6 pyruvoyl tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1);
6 pyruvoyl tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha;
DCoH;
Dimerization cofactor of hepatic nuclear factor 1 alpha;
Dimerization cofactor of hepatocyte nuclear factor 1 alpha;
Dimerization cofactor of hepatocyte nuclear factor 1-alpha;
Dimerization cofactor of HNF1;
Dimerizing cofactor for HNF1;
PCBD 1;
PCBD;
PCBD1;
PCD;
Phenylalanine hydroxylase stimulating protein;
Phenylalanine hydroxylase-stimulating protein;
PHS;
PHS_HUMAN;
Pterin 4 alpha carbinolamine dehydratase;
Pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1);
Pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha;
Pterin carbinolamine dehydratase;
Pterin-4-alpha-carbinolamine dehydratase.

Mouse,Human,Rat,Cow,Rabbit

WB,IHC,IF,ICC

WB 1:500-2000
IHC 1:100-500
IF 1:100-1:400
ICC 1:100-1:400

12kD

5092

P61457

https://www.uniprot.org/uniprotkb/P61457

Cytoplasm. Nucleus. Cytoplasmic and/or nuclear.

KLH conjugated synthetic peptide derived from human PCBD1

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.