The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Alpha CP2;
Alpha-CP2;
alphaCP-2;
Cbp;
CTBP;
Heterogeneous nuclear ribonucleoprotein E2;
Heterogenous nuclear ribonucleoprotein E2;
hnRNP E2;
hnRNP-E2;
HNRNPE2;
Hnrnpx;
HNRPE2;
Hnrpx;
MGC110998;
PCBP2;
PCBP2_HUMAN;
poly(rC) binding protein 2;
Poly(rC)-binding protein 2;
Putative heterogeneous nuclear ribonucleoprotein X;
rCbinding protein 2.

Mouse,Human,Rat,Pig,Cow,Rabbit,Zebrafish,Sheep

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

39kD

5094

Q15366

https://www.uniprot.org/uniprotkb/Q15366

Nucleus. Cytoplasm. Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.

Detected in all tissues examined.

KLH conjugated synthetic peptide derived from human PCBP2

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.