The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. BRSK2 (BR serine/threonine kinase 2), also known as SAD1, STK29 or PEN11B, is a 736 amino acid protein that contains one protein kinase domain and is preferentially expressed in brain and testis. One of several members of the Ser/Thr protein kinase family, BRSK2 uses magnesium as a cofactor to catalyze the ATP-dependent phosphorylation of target proteins and is thought to be involved in microtubule assembly, neuronal polarization and synaptic development. Additionally, BRSK2 may function as an autoantigen involved in small-cell lung cancer-associated limbic encephalitis. Five isoforms of BRSK2 exist due to alternative splicing events.

BR serine/threonine kinase 2; BR serine/threonine-protein kinase 2; Brain selective kinase 2; Brain specific serine/threonine protein kinase 2; Brsk2; BRSK2_HUMAN; C11orf7; PEN11B; Protein kinase SAD1B; SAD1; Serine/threonine kinase 29; Serine/threonine protein kinase BRSK2; Serine/threonine-protein kinase 29; Serine/threonine-protein kinase SAD-A; STK29; SADA.

Mouse,Human,Rat,Chicken,Dog,Pig,Cow,Horse,Sheep

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

82kD

9024

Q8IWQ3

https://www.uniprot.org/uniprotkb/Q8IWQ3

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.
Contains 1 protein kinase domain.

KLH conjugated synthetic peptide derived from human STK29

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.