RNA polymerase (pol) III synthesizes tRNA, 5s rRNA, 7SL RNA and U6 snRNA and is overexpressed in many transformed cell lines and tumors in vivo, since cells must duplicate its protein components before division. Therefore, in order to maintain rapid growth, cells must produce a high level of Pol III transcribed RNA, which requires the presence of the TFIIIB and TFIIIC2 transcription factor complexes. The TFIIIC2 complex is composed of five subunits, TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, that are overexpressed in adenovirus transformed cells as well as in malignant cells in vivo, such as ovarian carcinomas. TFIIIC2 recruits RNA pol III and TFIIIB to promoter elements and may be a key component in the deregulation of malignant cells. The TFIIIB complex includes the TATA-binding protein (TBP), TFIIB-related factor 1 (BRF1) and TFIIIB’’, the expression of which are also upregulated in transformed cells. In many carcinomas, the tumor suppressors retinoblastoma (RB) and p53 are inactivated, which affects their ability to bind and inactivate the function of TFIIIB.

EC 2.3.1.48;
FLJ21002;
General transcription factor 3C 4;
General transcription factor 3C polypeptide 4;
General transcription factor IIIC, polypeptide 4, 90kDa;
GTF3C4;
KAT12;
MGC138450;
OTTHUMP00000022434;
TF3C delta;
TF3C-delta;
TF3C4_HUMAN;
TFIII90;
TFIIIC 90 kDa subunit;
TFiiiC2 90;
TFIIIC290;
TFIIIC90;
TFIIICdelta;
Transcription factor IIIC 90 kDa subunit;
Transcription factor IIIC subunit delta.

Mouse,Human,Rat,Dog,Horse,Rabbit

WB,IHC,IF,ICC

WB 1:500-2000
IHC 1:100-500
IF 1:100-1:400
ICC 1:100-1:400

92kD

9329

Q9UKN8

https://www.uniprot.org/uniprotkb/Q9UKN8

Nucleus.

KLH conjugated synthetic peptide derived from human GTF3C4

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.