This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. [provided by RefSeq, Jan 2013]

FLJ14425;
FLJ40413;
FLJ90519;
I 1;
I 1 receptor candidate protein;
I1R candidate protein;
Imidazoline 1 receptor candidate protein;
Imidazoline receptor 1; NISCH_HUMAN;
Imidazoline receptor antisera selected;
Imidazoline receptor antisera selected protein;
Imidazoline receptor candidate;
IR1;
IRAS;
KIAA0975;
Nischarin.

Mouse,Rat,Dog,Pig,Cow

WB

WB 1:500-2000

167kD

11188

Q9Y2I1

https://www.uniprot.org/uniprotkb/Q9Y2I1

Cell membrane. Cytoplasm. Early endosome. Recycling endosome.

Isoform 1, isoform 3 and isoform 4 are expressed in brain. Isoform 1 is expressed in endocrine tissues.

KLH conjugated synthetic peptide derived from human NISCH

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.