LPP (LIM containing lipoma preferred partner), is a scaffolding protein which contains three LIM domains at its carboxy terminus, preceded by a proline rich pre LIM region containing a number of protein interaction domains. LPP localizes to sites of cell adhesion, such as focal adhesions and cell-cell contacts and may be involved in cell-cell adhesion and cell motility. LPP also shuttles through the nucleus and may function as a transcriptional co-activator. The human LPP gene maps to chromosomal location 3q28, and preferentially translocates to the HMGIC gene in a subclass of human benign mesenchymal tumors known as lipomas. Alternate splicing results in multiple transcript variants.

DKFZp779O0231;
FLJ30652;
FLJ41512;
LIM domain containing preferred translocation partner in lipoma;
LIM domain-containing preferred translocation partner in lipoma;
LIM protein;
Lipoma preferred partner;
Lipoma-preferred partner;
lpp;
LPP_HUMAN.

Mouse,Human,Rat,Chicken,Dog,Cow,Horse,Rabbit

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

80kD

4026

Q93052

https://www.uniprot.org/uniprotkb/Q93052

Nucleus. Cytoplasm. Cell junction. Cell membrane. Found in the nucleus, in the cytoplasm and at cell adhesion sites. Shuttles between the cytoplasm and the nucleus. It has been found in sites of cell adhesion such as cell-to-cell contact and focal adhesion which are membrane attachment sites of cells to the extracellular matrix. Mainly nuclear when fused with HMGA2/HMGIC and MLL.

Expressed in a wide variety of tissues but no or very low expression in brain and peripheral leukocytes.

KLH conjugated synthetic peptide derived from human LIM protein

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.