Glucose and insulin are anabolic signals which upregulate the transcriptions of a series of lipogenic enzymes to convert excess carbohydrate into triglycerides for efficient energy storage. DGAT1 is a microsomal enzyme that assists in the synthesis of fatty acids into triglycerides. DGAT catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol (DAG) and fatty acyl CoA as substrates. DGAT plays a fundamental role in the metabolism of cellular diacylglycerol and is important in higher eukaryotes for physiologic processes involving triacylglycerol metabolism such as intestinal fat absorption, lipoprotein assembly, adipose tissue formation, and lactation. DGAT1 is involved in fat absorption in the intestine and in basal level triglyceride synthesis in adipose tissue, where it is more highly expressed.

ACAT related gene product 1;
ACAT-related gene product 1;
Acyl coenzyme A:cholesterol acyltransferase related gene 1;
Acyl-CoA retinol O-fatty-acyltransferase;
Acyl-CoA:diacylglycerol acyltransferase;
ARAT;
ARGP1;
C75990;
D15Ertd23e;
Dgat;
DGAT1;
DGAT1_HUMAN;
Diacylglycerol O acyltransferase 1;
Diacylglycerol O-acyltransferase 1;
Diglyceride acyltransferase;
EC 2.3.1.20;
hCG_24006;
MGC139064;
Retinol O fatty acyltransferase.

Human,Mouse,Rat,Dog,Pig,Horse

WB,IHC,IF,ICC

WB 1:500-2000
IHC 1:100-500
IF 1:100-1:400
ICC 1:100-1:400

55kD

8694

O75907

https://www.uniprot.org/uniprotkb/O75907

Endoplasmic reticulum membrane; Multi-pass membrane protein.

KLH conjugated synthetic peptide derived from human DGAT1

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.