This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]

Deafness autosomal recessive 10;
DFNB10;
DFNB8;
ECHOS1;
Gene similar to transmembrane serine protease;
MGC130589;
Serine protease TADG-12;
si:dz69g10.3;
TADG12;
TMPRSS 3;
TMPRSS3;
TMPS3_HUMAN;
Transmembrane protease serine 3;
Tumor associated differentially expressed gene 12 protein;
Tumor-associated differentially-expressed gene 12 protein;
UNQ323/PRO382.

Rat,Human,Mouse,Dog,Pig,Cow,Sheep

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

49kD

64699

P57727

https://www.uniprot.org/uniprotkb/P57727

Endoplasmic reticulum membrane.

Expressed in many tissues including fetal cochlea. Isoform T is found at increased levels in some carcinomas.

KLH conjugated synthetic peptide derived from human TMPRSS3

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.