The NPL4 gene encodes the 608-amino acid, endoplasmic reticulum and nuclear membrane protein Npl4 that forms a complex with p97/Cdc48p and Ufd1p. This complex plays a role in IP3 receptor processing by recognizing ubiquitinated IP3 receptors in the endoplasmic reticulum and delivering them to the proteasome for degradation. The Npl4 protein contains 8 potential N-myristoylation sites, 5 potential N-glycosylation sites, several phosphorylation sites, and a C-terminal zinc finger motif. This protein is 96% homologous to the rat Npl4 protein, 44% homologous to the Caenorhabditis elegans Npl4 protein, and 34% homologous to the Saccharomyces cerevisiae Npl4 protein. Mutations in the NPL4 gene cause defects in nuclear envelope morphology, nuclear protein import, and nuclear poly(A) RNA export.

KIAA1499;
NPL4;
NPL4, S. cerevisiae, homolog of;
NPL4_HUMAN;
nploc4;
nuclear protein localization 4 homolog (S. cerevisiae);
Nuclear protein localization 4 homolog;
Nuclear protein localization protein 4 homolog;
Nuclear protein localization protein 4, S. cerevisiae, homolog of;
Protein NPL4.

Mouse,Rat,Human,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

68kD

55666

Q8TAT6

https://www.uniprot.org/uniprotkb/Q8TAT6

Cytoplasm; cytosol. Endoplasmic reticulum. Nucleus. Associated with the endoplasmic reticulum and nuclear.

Expressed at highest levels in brain, heart, skeletal muscle, kidney and fetal liver.

KLH conjugated synthetic peptide derived from human NPL4

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.