The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. The Hox11 gene, termed an orphan homeobox gene, as it is located outside of the four mammalian Hox clusters, is a DNA-binding nuclear transcription factor. The human Hox11 gene maps to chromosome 10q24 and has been implicated in the chromosomal translocation t(7;10)(q24;q11) that occurs in T-cell acute lymphoblastic leukemia (T-ALL). The t(7:10) translocation occurs between the Hox11 gene and the T-cell receptor (TCR) delta-chain gene and is a result of aberrant physiological recombinational events at the early stages of T-cell development. The Hox11 gene is normally expressed in the splanchnic anlage arising from the splanchnic mesoderm. Homozygous Hox11-deficient mice have no spleen, while all other splanchnic derivatives develop normally. Spleen development starts and proceeds normally in Hox11-deficient mice to a specific stage of embryogenesis, when the spleen anlage becomes fully absorbed.

Homeo box 11 (T cell leukemia 3 associated breakpoint homologous to Drosophila Notch);
Homeo box 11 (T cell lymphoma 3 associated breakpoint);
Homeobox 11;
Homeobox protein Hox 11;
Homeobox protein Hox-11;
Homeobox TLX-1;
Hox-11;
Hox11;
MGC163402;
OTTHUMP00000020816;
Proto oncogene TCL 3;
Proto-oncogene TCL-3;
RGD1563655;
T cell leukemia homeobox protein 1;
T cell leukemia lymphoma protein 3;
T-all, included;
T-cell acute lymphocytic leukemia, included;
T-cell leukemia 3 gene;
T-cell leukemia homeobox protein 1;
T-cell leukemia, homeobox 1;
T-cell leukemia/lymphoma protein 3;
TCL 3 proto oncogene;
TCL3;
Tlx-1;
TLX1;
TLX1_HUMAN.

Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Zebrafish,Sheep

WB

WB 1:500-2000

34kD

3195

P31314

https://www.uniprot.org/uniprotkb/P31314

Nucleus.

KLH conjugated synthetic peptide derived from human TCL3/HOX11

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.