HOX genes play a fundamental role in the development of the vertebrate central nervous system, heart, axial skeleton, limbs, gut, urogenital tract and external genitalia. The homeobox gene Hoxb-1 is critical to hindbrain development and has phenotypic features frequently observed in autism. Analysis of expression and targeted disruption of Hoxb-1 demonstrates that it is also essential for patterning progenitor cells along the entire DV axis of rhombomere 4 (r4). Hoxb-1 maintains this function by acting very early during hindbrain neurogenesis to specify effectors of the sonic hedgehog and Mash1 signaling pathways. Hoxb2 is a homeodomain protein important in neural development that is also expressed during erythropoiesis, hindbrain development and normal human adult lung development. Hoxb2 may modulate the amount of gamma-globin mRNA expressed during development and differentiation. In addition, Hoxb2 plays an important role in the patterning of hindbrain and pharyngeal arches in the zebrafish.

HCFP3;
Homeo box 2I;
Homeo box B1;
Homeobox 2I;
Homeobox B1;
Homeobox protein Hox B1;
Homeobox protein Hox-2I;
Homeobox protein Hox-B1;
Homeobox protein HoxB1;
Homeobox2I;
HomeoboxB1;
HOX 2;
Hox 2.9;
HOX 2I;
HOX B1;
HOX2;
Hox2.9;
HOX2I;
HOXB 1;
HOXB1;
HOXB1 protein;
HXB1_HUMAN;
MGC116843;
MGC116844;
MGC116845.

Human,Mouse,Pig,Rabbit

WB

WB 1:500-2000

32kD

3211

P14653

https://www.uniprot.org/uniprotkb/P14653

Nucleus.

KLH conjugated synthetic peptide derived from human HOXB1

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.