The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. [provided by RefSeq, Jul 2008]

STAT5a (phospho S726); p-STAT5a (phospho S726); STA5A_HUMAN; STAT5A(phospho S726); Mammary gland factor; Mammary gland factor; MGF; MGF; Signal transducer and activator of transcription 5A; Signal transducer and activator of transcription 5A; STAT 5; STAT 5A; STAT5A.

Human,Rat,Mouse,Chicken,Dog,Pig,Cow,Rabbit,Sheep

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

91kD

6776

P42229

https://www.uniprot.org/uniprotkb/P42229

Cytoplasm. Nucleus. Note=Mostly cytoplasmic during pregnancy, whereas it becomes predominantly nuclear during early lactation. It is translocated into the nucleus in response to phosphorylation.

Expressed in heart, lung, and weakly in muscle.

KLH conjugated Synthesised phosphopeptide derived from human STAT5a around the phosphorylation site of Ser726

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.