The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. Expressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta. Belongs to the ligand-gated ionic channel (TC 1.A.9) family.

5 HT 3; 5 HT3; 5 HT3A; HTR-3A; 5 HT3A receptor; 5 HT3R; 5 HT3RA; 5 hydroxytryptamine (serotonin) receptor 3A; 5 Hydroxytryptamine receptor 3; 5-HT-3; 5-HT3-A; 5-HT3A; 5-HT3R; 5-hydroxytryptamine receptor 3; 5-hydroxytryptamine receptor 3A; 5HT 3; 5HT 3A; 5HT receptor; 5HT3 serotonin receptor; 5HT3A_HUMAN; 5HT3R; HTR 3; HTR3; Htr3a; Serotonin gated ion channel receptor; Serotonin receptor 3; Serotonin receptor 3A; Serotonin-gated ion channel receptor 3a; 5HT3A_HUMAN.

Mouse,Rat,Human

WB

WB 1:500-2000

53kD

3359

P46098

https://www.uniprot.org/uniprotkb/P46098

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Expressed in brain. Higher levels of expression are observed in the cerebellum, occipital cortex and frontal cortex.

Recombinant human 5-HTR3

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.