This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008]

HIRA (phospho T555); p-HIRA (phospho T555); DGCR1;
DGGR 1;
DGGR1;
DiGeorge critical region gene 1;
HIR;
HIR histone cell cycle regulation defective homolog A;
HIRA;
HIRA protein;
HIRA_HUMAN;
Protein HIRA;
TUP 1;
TUP1;
TUP1 like enhancer of split protein 1;
TUP1-like enhancer of split protein 1;
TUPLE 1;
TUPLE1.

Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep

WB

WB 1:500-2000

112kD

7290

P54198

https://www.uniprot.org/uniprotkb/P54198

Nucleus. Nucleus > PML body. Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence.

Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart, liver, lung, and placenta.

KLH conjugated synthesised phosphopeptide derived from human HIRA around the phosphorylation site of Thr555

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.