Mcl1 is an anti-apoptotic member of Bcl2 family originally isolated from the ML1 human myeloid leukemia cell line during phorbol ester-induced differentiation along the monocyte/macrophage pathway. Mcl1 localizes to the mitochondria, interacts with and antagonizes pro-apoptotic Bcl2 family members, and inhibits apoptosis by a number of cytotoxic stimuli. It is involved in programing of differentiation and concomitant maintenance of viability but not of proliferation. Isoform 1 inhibits apoptosis while isoform 2 promotes it. Expression increases early during phorbol-ester induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell lines ML1.

MCL1 (phospho S159); p-MCL1 (phospho S159);
Bcl 2 related protein EAT/mcl1;
Bcl-2-like protein 3;
Bcl-2-related protein EAT/mcl1;
BCL2 related;
Bcl2-L-3;
BCL2L3;
EAT;
Induced myeloid leukemia cell differentiation protein Mcl 1;
Induced myeloid leukemia cell differentiation protein Mcl-1;
MCL 1;
MCL1;
MCL1-ES;
Mcl1/EAT;
MCL1_HUMAN;
MCL1L;
MCL1S;
MGC104264;
MGC1839;
Myeloid Cell Leukemia 1;
Myeloid cell leukemia ES;
Myeloid cell leukemia sequence 1;
Myeloid cell leukemia sequence 1 BCL2 related;
Myeloid cell leukemia sequence 1 isoform 1;
OTTHUMP00000032794;
OTTHUMP00000032795;
TM.

Human,Mouse,Rat,Pig,Horse,Rabbit

IHC,IF,ICC

IHC 1:100-500
IF 1:100
ICC 1:100-1:400

37kD

4170

Q07820

https://www.uniprot.org/uniprotkb/Q07820

Membrane; Single-pass membrane protein (Potential). Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria.

KLH conjugated synthesised phosphopeptide derived from human Mcl 1 around the phosphorylation site of Ser159.

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.