Torsin3A is a 397 amino acid member of the clpA/clpB family of proteins. Localized to the cytoplasm and the endoplasmic reticulum, Torsin3A is most highly expressed in stomach, lymph nodes and salivary glands. Torsin3A contains a hydrophobic N-terminal sequence, an ATP binding domain and 8 putative phosphorylation sites. Highly homologous with TorsinA and TorsinB, Torsin3A is thought to be related to the AAA chaperone-like family of ATPases. Members of this family play a role in the assembly, disassembly and operation of a variety of protein complexes, confer increased tolerance to high temperature and promote specific proteolysis. Torsin3A is also referred to as an interferon responsive gene, as interaction with type 1 interferons (IFN-alpha and IFN-beta) cause a 5 to 40 fold increase in Torsin3A mRNA levels. Three isoforms of Torsin3A exist as a result of alternative splicing events, and isoform 2 is expressed exclusively in the placenta

ADIR;
ADIR2;
ATP dependant interferon response protein 1;
ATP dependant interferon responsive;
ATP dependent interferon responsive protein;
ATP-dependent interferon-responsive protein;
FLJ22345;
MGC111104;
Tor3a;
TOR3A_HUMAN;
torsin 3A;
Torsin family 3 member A;
torsin family 3, member A;
Torsin-3A
torsin family 3, member A;
Torsin3A;

Human,Rat,Mouse,Pig,Cow,Horse,Sheep

WB,IHC,IF,ICC

WB 1:500-2000
IHC 1:100-500
IF 1:100-1:400
ICC 1:100-1:400

43kD

64222

Q9H497

https://www.uniprot.org/uniprotkb/Q9H497

Cytoplasm. Endoplasmic reticulum.

Ubiquitously expressed. Highest expression in stomach, salivary glands and lymph nodes. Isoform 2 is expressed in placenta.

KLH conjugated synthetic peptide derived from human TOR3A

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.