The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010].

NCOA3_HUMAN; Nuclear receptor coactivator 3; EC:2.3.1.48; NCoA-3; ACTR; Amplified in breast cancer 1 protein (AIB-1); CBP-interacting protein (pCIP); Class E basic helix-loop-helix protein 42 (bHLHe42); Receptor-associated coactivator 3 (RAC-3); Steroid receptor coactivator protein 3 (SRC-3); Thyroid hormone receptor activator molecule 1 (TRAM-1); AIB1; RAC3; SRC3; pCIP; AIB-1; CTG26; SRC-3; CAGH16; KAT13B; TNRC14; TNRC16; TRAM-1; bHLHe42;

Human,Pig,Horse,Rabbit,GuineaPig

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

155kD

8202

Q9Y6Q9

https://www.uniprot.org/uniprotkb/Q9Y6Q9

Cytoplasm. Nucleus. Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus.

Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney.

KLH conjugated Synthesised phosphopeptide derived from human SRC-3 around the phosphorylation site of Thr24

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.