Mecr is a 373 amino acid mitochondrial protein that may play a role in fatty acid synthesis. Existing as two alternatively spliced isoforms, Mecr is highly expressed in cardiac and skeletal muscle, with lower levels found in pancreas, kidney, placenta and liver. Mecr forms a homodimer and belongs to the zinc-containing alcohol dehydrogenase family and quinone oxidoreductase subfamily. Mecr reduces trans-2-enoyl-CoA to acyl-CoA in an NADPH-dependent manner and is encoded by a gene that maps to human chromosome 1p35.3. Human chromosome 1 spans 260 million base pairs, contains over 3,000 genes, comprises nearly 8% of the human genome and houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome.

AI195831;
CGI 63;
FASN2B;
Homolog of yeast 2 enoyl thioester reductase;
HsNrbf-1;
HsNrbf1;
mecr;
MECR_HUMAN;
Mitochondrial 2 enoyl thioester reductase;
mitochondrial;
NRBF 1;
NRBF-1;
NRBF1;
Nuclear receptor binding factor 1;
Nuclear receptor-binding factor 1;
OTTMUSP00000009996;
RP23-13A13.1;
Trans 2 enoyl CoA reductase, mitochondrial;
Trans-2-enoyl-CoA reductase.

Mouse,Human,Rat,Rabbit,Sheep

WB,IHC,IF,ICC

WB 1:500-2000
IHC 1:100-500
IF 1:100-1:400
ICC 1:100-1:400

36kD

51102

Q9BV79

https://www.uniprot.org/uniprotkb/Q9BV79

Mitochondrion.

Highly expressed in skeletal and heart muscle. Expressed at lower level in placenta, liver, kidney and pancreas. Weakly or not expressed in lung.

KLH conjugated synthetic peptide derived from human MECR

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.