PC18763

货号 规格 价格(¥)
PC18763S 50ul
PC18763M 100ul

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Note:  Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.

注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。

抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。

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经典一抗-MED12/Trap230 Rabbit pAb

Datasheet

Background

The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009]

Alternative Names

Activator recruited cofactor 240 kDa component;
Activator-recruited cofactor 240 kDa component;
Activator-recruited cofactor 240 kDa component;
ARC240;
CAG repeat protein 45;
CAGH45;
HOPA;
KIAA0192;
MED12;
MED12_HUMAN;
Mediator complex subunit 12;
Mediator of RNA polymerase II transcription subunit 12;
Mediator of RNA polymerase II transcription subunit 12;
Mediator of RNA polymerase II transcription subunit 12;
OPA containing protein;
OPA-containing protein;
OPA-containing protein;
Thyroid hormone receptor associated protein complex 230 kDa component;
Thyroid hormone receptor-associated protein complex 230 kDa component;
Thyroid hormone receptor-associated protein complex 230 kDa component;
TNRC11;
Trap230;
Trinucleotide repeat containing gene 11 protein;
Trinucleotide repeat-containing gene 11 protein;
Trinucleotide repeat-containing gene 11 protein.

Reactivity

Mouse,Rat,Human,Pig,Cow,Rabbit,Sheep

Application

WB,IHC,IF,ICC

Recommended Dilution

WB 1:500-2000
IHC 1:100-500
IF 1:100-1:400
ICC 1:100-1:400

Application Image

Mol Weight

243kD

Gene ID

9968

UniProt

Q93074

Uniprot link

Subcellular location

Nucleus.

Specificity

Ubiquitous.

Immunogen

KLH conjugated synthetic peptide derived from human MED12/Trap230

Source

Rabbit

Clonality

Polyclonal

Isotype

IgG

Purification

affinity purified by Protein A

Formulation

Liquid

Buffer

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Concentrate

Storage Condition

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

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      微信客服

邮箱:market@ab-mart.com

应聘职位:hr@ab-mart.com

订购专线:4006-123-828

销售电话:13916964679(微信同号)

技术支持:15618194176(微信同号)

华南经销商负责(广东,广西,福建,海南):
程经理:手机18616261485(微信同号)
华北经销商负责(北京,天津,河北):
徐经理:手机15618191473(微信同号)
南方经销商负责:

陆经理:手机13122837132(微信同号)
北方及西南经销商负责:

张经理:手机13122150513(微信同号)

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